Duke Center for Cerebrovascular Disease
The Duke Stroke Center

CURRENT STROKE-RELATED CLINICAL RESEARCH STUDIES
Click on the Principal Investigator's name to learn more about their research programs and interests.

Duke-American Stroke Association Bugher Foundation Center for Stroke Prevention Research
Principal Investigator: Larry B. Goldstein, MD
Center-sponsored clinical research activities include studies aimed at determining genetic factors affecting the risk and consequences of small-vessel-type intracranial vascular disease.

Amphetamine-Enhanced Stroke Recovery
Principal Investigator: Larry B. Goldstein, MD
This is an NIH-supported, prospective, randomized pilot study aimed at studying the potential benefit of treatment with amphetamine combined with physical therapy in enhancing poststroke recovery in patients with ischemic stroke who have a motor deficit (difficulty walking and/or using and arm) and who can begin treatment between 10 and 30 days after stroke. No subjects are currently being enrolled.

Carotid Revascularization Endarterectomy vs. Stent Trial (CREST)
Principal Investigators: Richard L. McCann, MD, Tony Smith, MD; Larry B. Goldstein, MD,
CREST is an NIH-supported, prospective, randomized study to evaluate the safety and efficacy of carotid angioplasty and stenting vs. carotid endarterectomy in patients with symptomatic extracranial carotid artery stenosis. CREST has completed enrollment and is currently in the follow-up phase.

Randomized Evaluation of Recurrent Stroke comparing PFO Closure to Established Current Standard Treatment (RESPECT)
Principal Investigator: Larry B. Goldstein, MD
This is a multicenter randomized trial with comparing device closure of patent foramen ovale (PFO) with medical therapy in persons who have this condition and who have had an ischemic stroke within the previous 270 days of otherwise unknown cause.

COSS
Principal Investigator: Carmen Graffagnino, MD
This is a multicenter, NIH-supported randomized controlled study evaluating intracranial-extracranial bypass surgery for patients who have had symptoms related to complete occlusion of a carotid artery within the prior 120 days.

Albumin in Acute Stroke Study (ALIAS)
Principal Investigator: Daniel Laskowitz, MD
This is an NIH-supported, Phase III randomized multicenter clinical trial. The primary objective is to determine whether the administration of human albumin increases the proportion of patients with acute ischemic stroke having favorable outcomes as compared to placebo after 3 months from randomization.

The Evaluation of Patient with Acute Hypertension and Intracerebral Hemorrhage with Intravenous Clevedipine Treatment (ACCELERATE)
Principal Investigator: Carmen Graffagnino, MD
The purpose of this study is to evaluate the efficacy and safety of an intravenous infusion of clevedipine for the treatment of acute hypertension in patients with intracerebral hemorrhage.

Minimally Invasive Surgery Plus rt-PA for ICH Evacuation (MISTe)
Principal Investigator: Carmen Graffagnino, MD
The purpose of this NIH-sponsored clinical trial is to evelaute stereotactic lysis and clot extraction in patients with a deep hemorrhageage.

RECENTLY COMPLETED STROKE-RELATED CLINICAL RESEARCH STUDIES

Prevention Regimen For Effectively Avoiding Secondary Strokes (PRoFESS)
Principal Investigator: Larry B. Goldstein, MD
This was a multicenter randomized trial comparing clopidogrel (Plavix) vs. aspirin + delayed release dipyridamole (Aggrenox) and Telmesartan vs. placebo for prevention of recurrent ischemic stroke. Results were presented at the 2008 European Stroke Conference.

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